POST-GUIDANCE SIGNALING BY EXTRACELLULAR MATRIX-ASSOCIATED SLIT/SLIT-N MAINTAINS FASCICULATION AND POSITION OF AXON TRACTS IN THE NERVE CORD.

Post-guidance signaling by extracellular matrix-associated Slit/Slit-N maintains fasciculation and position of axon tracts in the nerve cord.

Axon-guidance by Slit-Roundabout (Robo) signaling at the midline initially guides growth cones to synaptic targets and positions longitudinal axon tracts in discrete bundles on either side of the midline.Following the formation of commissural tracts, Slit is found also in tracts of the commissures and longitudinal connectives, the purpose of which

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Non-degradative Ubiquitination of Protein Kinases.

Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation.In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non-degradative ubiquitination modulates protein structure, dynamics, and function.Due to the wealth

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